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Olupese Ipese Cilengitide 98% funfun lulú CAS NO.188968-51-6

Cilengitid CAS NỌ: 188968-51-6
Cilengitide jẹ peptide pentapeptide cyclic ti o dije fun ọna peptide arginine-glycine-aspartate (RGD).Ṣe atunṣe isopọ integrin-ligand.Cilengitide ni yiyan ati imunadoko ni idaduro alpha v beta 3 beta ati alpha v 5 integrin ni idapo pẹlu awọn ọlọjẹ matrix, gẹgẹbi Vitronectin, Fibronectin, Fibrinogen, vonWillebrandFactor, Osteopontin, ati awọn miiran.Awọn 10μMCilengiChemicalbooktide ṣe idiwọ ifaramọ ti BAE, BME ati awọn sẹẹli HUVE patapata si Vitronectin ati Fibronectin.Cilengitide n ṣiṣẹ ni vitro lori awọn sẹẹli BAE ti a ti ṣaju pẹlu FGF-2 (tabi VEGF-A) ti collagen onisẹpo mẹta ati gel fibrin ẹjẹ lati dena angiogenesis pẹlu IC50 ti 15 ati 8μM, ati 4 ati 3μM, lẹsẹsẹ.Cilengitide ṣe idiwọ ilọsiwaju sẹẹli, nfa apoptosis sẹẹli endothelial, o si fa iyatọ sẹẹli endothelial precursor eniyan.


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Orukọ ọja Cilengitide
CAS 188968-51-6
molikula agbekalẹ C27H40N8O7
iwuwo molikula 588.66
iwuwo 1.41± 0.1 g/cm3 (Asọtẹlẹ)
solubility ≥29.43 mg / mL ni DMSO;≥22.56 mg/ml ni H2O
olùsọdipúpọ̀ acid (pKa) 4.01± 0.10 (Asọtẹlẹ)
atunto (1)
atunto (1)
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